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The agreement announced today ends a lawsuit brought in december 1990 by attorneys general in new jersey, new york, washington and 30 other states over the marketing of a sandoz drug called clozaril.

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UsesFor the treatment of severely ill patients with schizophrenia who fail to respond adequately to standard antipsychotic treatmentTo reduce the risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorderwho are judged to be at chronic risk for re-experiencing suicidal behaviorbased on history and recent clinical state.

If myocarditis or cardiomyopathy are suspectedClozaril treatment should be promptly stopped and the patient immediately referred to a cardiologistsee section 4.4

Orthostatic hypotensionwith or without syncopecan occur during Clozaril treatmentRarelycollapse can be profound and may be accompanied by cardiac and/or respiratory arrestSuch events are more likely to occur with concurrent use of a benzodiazepine or any other psychotropic agentsee section 4.5and during initial titration in association with rapid dose escalationon very rare occasions they may occur even after the first doseThereforepatients starting Clozaril treatment require close medical supervisionMonitoring of standing and supine blood pressure is necessary during the first weeks of treatment in patients with Parkinson’s disease.

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